Metabolism modulation

Metabolism modulation" refers to therapeutic approaches aimed at altering cellular metabolic pathways to treat disease, rather than a singular molecular target. Such modulation can shift energy substrate preference (e.g., from fatty acids to glucose in heart failure), interfere with cancer cell metabolism, or correct metabolic imbalances in metabolic disorders. Approaches and drugs termed "metabolic modulators" typically achieve their effects by inhibiting or activating key enzymes or regulatory checkpoints in metabolic pathways, and have been investigated in diverse contexts including cancer therapy, heart failure, and metabolic diseases[2][5]. This entry should not be treated as a specific molecular target but as an overarching strategy or therapeutic principle[2][5].

Other names

metabolic modulationmetabolic pathway modulationmetabolic reprogramming

Inhibition or activation of enzymes involved in metabolism (e.g., fatty acid oxidation inhibitors, glycolysis modulators); Shifting substrate utilization (e.g., increasing glucose metabolism, reducing fatty acid oxidation)