Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Metabotropic glutamate receptor 1 (mGluR1)
- Target
- mGluR1
- Molecular classification
- G protein-coupled receptor, GPCR, Group I metabotropic glutamate receptor
01
Overview
Metabotropic glutamate receptor 1 (mGluR1) is a G protein-coupled receptor with seven transmembrane domains. It plays a role in modulating synaptic transmission and neuronal excitability in the CNS, as well as angiogenesis and tumor progression in peripheral tissues. It is implicated in various neurological and psychiatric disorders, and cancer, making it an attractive drug target. Alternative splicing results in multiple isoforms with tissue-specific functions.
- Other names
- GRM1
02
Mechanism of action
Gq protein activation leading to PLCβ4 activation, IP₃ and DAG production, Ca²⁺ release, and protein kinase Cγ activation. TRPC3-mediated cation influx.
03
Biological functions
Modulates synaptic transmissionNeuronal excitabilityMotor coordinationSynaptic plasticitySynapse eliminationLearning and memory processesRegulation of anxietyRegulation of pain perceptionSignal transductionAngiogenesisCell proliferation
04
Disease associations
Alzheimer’s diseaseParkinson’s diseaseAnxietyDepressionSchizophreniaCancer
Beyond the preview
Go deeper on Metabotropic glutamate receptor 1 (mGluR1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Metabotropic glutamate receptor 1 (mGluR1).