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Metabotropic Glutamate Receptor 3 (mGluR3)
- Target
- mGluR3
- Molecular classification
- G protein-coupled receptor, GPCR, Class C GPCR, Metabotropic glutamate receptor, Receptor
01
Overview
Metabotropic glutamate receptor 3 (mGluR3) is a member of the group II metabotropic glutamate receptors and is encoded by the GRM3 gene. It is an inhibitory Gi/Go-coupled GPCR localized to presynaptic sites in classical neuronal circuits and, in some cortical regions, postsynaptically. It modulates glutamatergic neurotransmission, synaptic plasticity, and is implicated in learning, memory, anxiety, pain, and neuroprotection. Alterations in mGluR3 signaling are linked to impaired cognition and increased risk for schizophrenia. mGluR3 is a therapeutic target for neuropsychiatric disorders, with ongoing research focusing on selective ligands and allosteric modulators.
- Other names
- GRM3mGlu3
02
Mechanism of action
Gi/Go protein activation, inhibition of cAMP production, modulation of MAPK/ERK, mTOR/p70 S6 kinase, and PI3K pathways
03
Biological functions
Signal transductionModulation of neurotransmissionSynaptic plasticityNeuroprotectionLearningMemory formationAnxiety regulationPain perceptionInhibition of adenylyl cyclaseRegulation of neurotransmitter release
04
Disease associations
SchizophreniaCognitive impairmentNeuropsychiatric disorders
05
Safety considerations
Lack of highly selective ligands and antibodiesPotential for side effects with direct agonists/antagonists
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