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Metabotropic Glutamate Receptor 4 (mGluR4)
- Target
- mGluR4
- Molecular classification
- G protein-coupled receptor, GPCR, Metabotropic Glutamate Receptor, Receptor
01
Overview
Metabotropic glutamate receptor 4 (mGluR4) is a G-protein-coupled receptor that modulates neurotransmission by inhibiting adenylyl cyclase. It is primarily expressed in presynaptic terminals in the CNS, particularly in the cerebellum and basal ganglia. Activation or positive modulation of mGluR4 has shown potential therapeutic benefits in Parkinson’s disease, autoimmune disorders, CNS inflammation, and cancer.
- Other names
- GRM4Taste-GRM4
02
Mechanism of action
Upon ligand binding, mGluR4 activates Gi/o proteins, leading to inhibition of adenylyl cyclase and decreased cAMP production, ultimately reducing neurotransmitter release from presynaptic neurons.
03
Biological functions
Neurotransmission modulationInhibition of adenylyl cyclase activityRegulation of neuronal excitabilitySynaptic plasticityLearning and memoryAnxiety response modulationPain perceptionMotor controlImmune modulation within the CNSUmami taste sensation
04
Disease associations
Parkinson’s diseaseAutoimmune disordersCNS inflammationCancerNeurodegenerative disease
05
Interacting drugs
Glutamate
13 more in the full profile.
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