Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Metabotropic Glutamate Receptor Subtype 5 (mGluR5)
- Target
- mGluR5
- Molecular classification
- G-protein-coupled receptor, GPCR, Family C, Receptor
01
Overview
Metabotropic glutamate receptor subtype 5 (mGluR5) is a class C G-protein-coupled receptor predominantly expressed on the postsynaptic sites of neurons in the central nervous system. It is encoded by the *GRM5* gene. mGluR5 plays a critical role in modulating synaptic transmission, neuronal excitability, and plasticity.
- Other names
- GRM5
02
Mechanism of action
Positive and negative allosteric modulation of mGluR5
03
Biological functions
Signal transductionSynaptic transmission modulationNeuronal excitability modulationSynaptic plasticityLearningMemory formationAnxiety regulationPain perceptionLocomotor network activity
04
Disease associations
AddictionAnxiety disordersAlcohol use disorderNeurodegenerative diseaseHuntington's disease
Beyond the preview
Go deeper on Metabotropic Glutamate Receptor Subtype 5 (mGluR5).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Metabotropic Glutamate Receptor Subtype 5 (mGluR5).