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Target intelligence / Profile preview
Metabotropic Glutamate Receptor Type 1 (mGluR1)
- Target
- mGluR1
- Molecular classification
- G protein-coupled receptor, GPCR, Class C GPCR, Receptor
01
Overview
Metabotropic glutamate receptor type 1 (mGluR1/GRM1) is a class C GPCR primarily involved in modulating synaptic transmission via indirect signaling cascades following activation by L-glutamate. It plays essential roles throughout normal brain function but also contributes to disease states when dysregulated—including neurological disorders as well as certain cancers where it may drive tumor growth through effects on cell proliferation or angiogenesis. Its unique structure includes a large extracellular ligand-binding domain forming dimers necessary for function—a feature that underpins its complex regulation within neural circuits as well as emerging therapeutic interest beyond neurology into oncology research domains.
- Other names
- GRM1
02
Mechanism of action
Activates phospholipase C → IP3/DAG pathway
03
Biological functions
Signal transductionSynaptic plasticityLearningMemory formationAnxiety modulationPain perceptionRegulation of neuronal excitability
04
Disease associations
Neurological disordersCancerMelanomaBreast cancer
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