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Target intelligence / Profile preview
Metabotropic Glutamate Receptor Type 3 (mGluR3)
- Target
- mGluR3
- Molecular classification
- G-protein coupled receptor (GPCR), GPCR, group C
01
Overview
Metabotropic Glutamate Receptor 3 (mGluR3) is a G-protein coupled receptor that modulates cell excitability and synaptic transmission. It is involved in neuroprotection by promoting glutamate uptake in astrocytes and limiting neurotoxic microglial phenotypes. Dysfunctions in mGluR3 signaling are linked to cognitive impairment and increased risk for psychiatric disorders such as schizophrenia, making it a potential therapeutic target for CNS disorders.
- Other names
- GRM3Glutamate receptor, metabotropic 3
02
Mechanism of action
Gi/Go protein-coupled; inhibits cAMP cascade
03
Biological functions
Signal transductionModulates synaptic transmissionModulates cell excitabilityNeuroprotectionRegulation of glutamate releaseGlutamate uptake (astrocytes)Regulation of microglial activation
04
Disease associations
SchizophreniaCognitive impairmentAlzheimer's diseaseParkinson's diseaseAnxiety disordersDepressionNeuroinflammation
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