Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Metadherin (MTDH)
- Target
- MTDH
- Molecular classification
- Other (oncoprotein involved in various cellular processes)
01
Overview
Metadherin (MTDH), also known as astrocyte elevated gene-1 protein (AEG-1), is an oncoprotein involved in the development and progression of various cancers. It interacts with multiple signaling pathways, including NF-κB, PI3K/AKT, and Ras, contributing to tumorigenesis, metastasis, and chemoresistance. MTDH is highly expressed in cancers such as breast, prostate, and hepatocellular carcinoma, making it a potential therapeutic target for cancer treatment.
- Other names
- Astrocyte elevated gene-1 protein (AEG-1)LYRICLysine-rich CEACAM1 co-isolated proteinMetastasis adhesion protein
02
Mechanism of action
Potential mechanisms involve inhibiting oncogenic pathways such as NF-κB, PI3K/AKT, and Ras signaling.
03
Biological functions
Signal transductionCell proliferationCell migrationAngiogenesisAlternative splicingRNA-induced silencing complex (RISC) function
04
Disease associations
Cancer (breast, prostate, ovary, endometrium, glioblastoma, hepatocellular carcinoma)Metastasis
05
Safety considerations
Overexpression of MTDH is linked to chemoresistance and poor prognosis in various cancers.
06
Biomarkers
Elevated expression of MTDH is associated with poor clinical outcomes in several cancers.
Beyond the preview
Go deeper on Metadherin (MTDH).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Metadherin (MTDH).