Metal-Dependent Peroxidase

Metal-dependent peroxidases are a diverse group of enzymes that catalyze the oxidation of various substrates using hydrogen peroxide or other peroxides as oxidants. They typically contain a metal cofactor, most commonly iron within a heme group, which is essential for their catalytic activity. These enzymes play crucial roles in a wide range of biological processes, including detoxification, antioxidant defense, hormone synthesis, and immune responses. Different isoforms exhibit distinct substrate specificities and tissue distributions.

Other names

PeroxidaseHeme-dependent peroxidaseGlutathione peroxidaseHRP (Horseradish Peroxidase)Myeloperoxidase

Catalyzes the peroxide-dependent oxidation of substrates via a redox cycle involving metal ion (usually iron) oxidation and reduction.