Metal ion sequestration

Metal ion sequestration is a cellular process, not a single molecular entity or canonical drug target. It refers broadly to the binding, storage, and controlled release of metal ions (including iron, copper, manganese, zinc, and others) by proteins such as metallothioneins, ferritin, or via compartmentalization in organelles like lysosomes and vacuoles[5][2][1][3]. This process is essential for maintaining metal homeostasis, protecting cells from metal-induced toxicity, and ensuring bioavailability for metalloproteins[5][1]. Metal ion sequestration mechanisms are exploited pharmacologically via chelating agents in heavy metal poisoning and other conditions. However, "metal ion sequestration" is mechanistic terminology and does not name a unique protein, receptor, transporter, or enzyme[5][2][1]. Important clarification: The entry "Metal ion sequestration" does not correspond to a unique, molecularly defined drug target (e.g., a single protein or receptor). Instead, it refers to a biological process involving multiple molecular actors and mechanisms. Therefore, it should not be used as a canonical target name in drug discovery databases or structured target lists[5][2][1][3].

Other names

Metal ion bindingMetal sequestrationMetal chelationSequestering of metal ion

Chelation of free metal ions; Inhibition of metal-dependent enzymes in pathogens or tumor cells; Modulation of metal ion availability to disrupt biological processes