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Target intelligence / Profile preview
Metal-responsive Transcription Factor 1 (MTF-1)
- Target
- MTF-1
- Molecular classification
- Transcription factor, Zinc finger protein
01
Overview
Metal-responsive transcription factor 1 (MTF-1) is a highly conserved, zinc-dependent transcription factor that plays a central role in the regulation of genes involved in metal homeostasis and cellular stress responses. It binds to metal response elements (MREs) in the promoters of target genes, such as metallothioneins, and activates their transcription in response to heavy metals, oxidative stress, or hypoxia. MTF-1 is essential for embryonic development and liver function, and its disruption can lead to various pathological conditions, including increased susceptibility to metal toxicity, impaired immune responses, and potentially cancer.
02
Mechanism of action
MTF-1 is a transcription factor that binds to metal response elements (MREs) in the promoter regions of target genes, leading to increased gene expression upon activation by heavy metals or other stressors.
03
Biological functions
Metal homeostasisOxidative stress responseHypoxia responseImmune regulationTranscriptional regulation
04
Disease associations
CancerMetal toxicityDevelopmental defectsImpaired immune responses
05
Safety considerations
Disruption of metal homeostasisIncreased susceptibility to metal toxicityPotential developmental defectsPossible role in cancer susceptibility
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