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Metallophosphoesterase domain containing protein 2 (MPPED2)
- Target
- MPPED2
- Molecular classification
- Enzyme (metallophosphoesterase family), Other (non-receptor phosphodiesterase-like protein)
01
Overview
Metallophosphoesterase domain containing protein 2 (MPPED2) is a human protein encoded by the MPPED2 gene on chromosome 11p13. It belongs to the metallophosphoesterase family of enzymes, with weak phosphodiesterase activity in vitro. The protein is highly expressed in fetal brain tissue and is considered important in nervous system development. Decreased MPPED2 expression is reported in various cancers (including cervical, breast, and neuroblastoma), correlating with cell proliferation, differentiation, and apoptosis. While studied as a possible tumor suppressor and diagnostic marker in oncology, particularly in cervical carcinoma related to high-risk human papillomavirus, MPPED2 is not currently an established therapeutic target and has no approved drug modulators.
- Other names
- C11orf8MPPED2Metallophosphoesterase domain-containing protein 2
02
Mechanism of action
no known mechanisms based on direct drug targeting; its function is mainly studied as a native enzyme, not as a drug target
03
Biological functions
Regulation of cell differentiationRegulation of cell proliferationRegulation of apoptosisCentral nervous system development / neurodevelopment
04
Disease associations
Cancer (downregulated in several cancers including cervical, neuroblastoma, squamous cell carcinoma of the mouth, breast, and thyroid cancer)Wilms tumor, Aniridia, Genitourinary anomalies, and Impaired intellectual development syndrome (Genitourinary syndrome)Urofacial syndrome 1Potential tumor suppressor role
05
Biomarkers
Possible cancer biomarker (its expression is downregulated in several malignancies and investigated for association with cervical carcinoma progression and prognosis)
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