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Target intelligence / Profile preview
Metallothionein (MT)
- Target
- MT
- Molecular classification
- Protein family, Metal-binding protein
01
Overview
Metallothioneins (MTs) are a family of low-molecular-weight, cysteine-rich proteins characterized by a high metal content. They play crucial roles in metal homeostasis, detoxification of heavy metals, and antioxidant defense. MTs are widely distributed across various organisms and are involved in multiple biological processes, including neuroprotection, anticancer activity, and anti-inflammatory responses. They also serve as biomarkers for environmental monitoring and have potential applications in disease diagnosis and therapy.
- Other names
- MT-1MT-2MT-3MT-4
02
Biological functions
Metal homeostasisMetal transportMetal storageDetoxificationAntioxidant defenseNeuroprotectionRegulation of cellular signaling pathways
03
Disease associations
CancerInflammationNeurodegenerative diseaseHeavy metal poisoningMetal dysregulation
04
Biomarkers
Environmental monitoring (exposure to toxicants)Disease prediction/diagnosis related to metal dysregulation
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