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Cancer Cell Metastasis Pathways
- Molecular classification
- Biological Pathway, Cellular Process
01
Overview
Cancer cell metastasis pathways describe the complex series of biological processes that enable cancer cells to spread from the primary tumor to distant sites in the body. This involves a multistep process including local invasion, intravasation into blood or lymphatic vessels, survival in circulation, extravasation into distant tissues, and colonization to form secondary tumors. Key signaling pathways like Notch, Wnt, and Hedgehog, as well as processes like EMT and angiogenesis, play crucial roles.
- Other names
- MetastasisTumor MetastasisCancer SpreadMetastatic Cascade
02
Mechanism of action
Complex interplay of multiple signaling pathways and cellular processes, involving alterations in cell adhesion, motility, and microenvironment interactions. Therapeutic strategies aim to disrupt key steps in the metastatic cascade.
03
Biological functions
Cell migrationCell invasionAngiogenesisEpithelial-Mesenchymal Transition (EMT)Cell proliferationCell survival
04
Disease associations
Cancer progressionMetastatic disease
05
Safety considerations
Drug resistanceOff-target effectsTumor microenvironment complexityIncomplete understanding of metastatic mechanisms
06
Interacting drugs
Angiogenesis inhibitors (e.g., Bevacizumab)
4 more in the full profile.
07
Biomarkers
EMT markers (e.g., Vimentin, E-cadherin)Angiogenic factors (e.g., VEGF)Circulating tumor cells (CTCs)Metastasis-associated gene expression signatures
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