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Target intelligence / Profile preview
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1)
- Target
- MALAT1
- Molecular classification
- Long non-coding RNA (lncRNA)
01
Overview
MALAT1 is a highly conserved long non-coding RNA (lncRNA) with significant roles in cancer biology and gene regulation. It is implicated in several key cellular processes including gene expression, alternative splicing, and acts as an endogenous microRNA sponge. Elevated levels are associated with radio-/chemotherapy resistance and poor prognosis across multiple malignancies, making it a potential therapeutic target.
- Other names
- Nuclear-enriched abundant transcript 2NEAT2
02
Mechanism of action
Antisense oligonucleotides targeting MALAT1 reduce tumor growth and metastasis in preclinical mouse models.
03
Biological functions
Regulation of gene expressionModulation of alternative splicingMicroRNA spongeRegulation of cell cyclePromotes proliferationPromotes migrationPromotes invasionPromotes metastasis
04
Disease associations
Cancer
05
Safety considerations
Context-dependent roles; MALAT1 may act as a metastasis suppressor under certain conditions.
06
Interacting drugs
Antisense oligonucleotides
07
Biomarkers
Elevated MALAT1 levels are associated with poor prognosis and therapy resistance
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