Metastasis-associated protein MTA3 (MTA3)

Metastasis-associated protein MTA3 is a nuclear protein encoded by the MTA3 gene in humans, primarily known as a component of the nucleosome remodeling and deacetylase (NuRD) complex, which regulates gene expression by modifying chromatin structure[1][4][5]. MTA3 acts as a transcriptional corepressor and is involved in maintaining epithelial identity by repressing genes involved in epithelial-to-mesenchymal transition (EMT), such as SNAI1. In breast and other cancers, MTA3 expression is often reduced, and its loss promotes EMT and cancer cell invasiveness, contrasting with the oncogenic roles of MTA1 and MTA2. MTA3 also regulates cell cycle progression, particularly the G2/M transition, via modulation of cyclin B expression in granulosa cells[3]. While it plays crucial roles in tumor suppression and cell proliferation, it is not currently a direct therapeutic target, receptor, or enzyme for drug development[1][4][5][6].

Other names

MTA3KIAA1266metastasis associated gene family, member 3metastasis-associated protein MTA3