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Target intelligence / Profile preview
Methaemoglobin (MetHb)
- Target
- MetHb
- Molecular classification
- Metalloprotein, Hemoglobin derivative
01
Overview
Methaemoglobin (MetHb) is a form of hemoglobin with iron in the ferric (Fe³⁺) state, unable to bind or transport oxygen. Elevated levels cause methemoglobinemia, impairing tissue oxygenation. It is normally kept at low levels by the enzyme cytochrome b5-methemoglobin reductase. Methemoglobinemia can be inherited or acquired through exposure to certain drugs or chemicals.
- Other names
- Methemoglobin
02
Mechanism of action
Methylene blue accelerates reduction of methaemoglobin back to hemoglobin.
03
Biological functions
Oxygen transport impairmentOxidation of hemoglobin
04
Disease associations
MethemoglobinemiaHypoxiaCyanosis
05
Safety considerations
HypoxiaCyanosisTissue oxygenation impairmentMethylene blue side effects
06
Interacting drugs
Benzocaine
2 more in the full profile.
07
Biomarkers
Methaemoglobin levels (measured by CO-oximetry)
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