Target intelligence / Profile preview

Methamphetamine (Meth)

Target
Meth
Molecular classification
Substituted phenethylamine, Amphetamine
01

Overview

Methamphetamine is a synthetic stimulant drug with a high potential for addiction and abuse. It acts primarily by increasing synaptic concentrations of monoamine neurotransmitters—dopamine, norepinephrine, and serotonin—by promoting their release from presynaptic neurons and inhibiting their reuptake. It is used medically for ADHD and obesity but is primarily encountered as a drug of abuse.

Other names
Crystal methIceTinaSpeedUppersChalkGlassDesoxyn
02

Mechanism of action

Increases synaptic concentrations of dopamine, norepinephrine, and serotonin by promoting their release and inhibiting their reuptake.

03

Biological functions

Central nervous system stimulantMonoamine neurotransmitter release enhancerMonoamine reuptake inhibitor
04

Disease associations

ADHDObesitySubstance use disorderNeurotoxicity
05

Safety considerations

AddictionCardiovascular complications (hypertension, tachycardia, stroke)Psychiatric disorders (paranoia, hallucinations, violent behavior)NeurotoxicityMeth mouthMovement disorders
06

Interacting drugs

Desoxyn

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