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Methanobrevibacter smithii
- Molecular classification
- Archaea, Methanogen
01
Overview
Methanobrevibacter smithii is a single-celled, anaerobic archaeon that is the predominant methanogenic microorganism in the human gut microbiota. It plays a crucial role in the efficient digestion of complex polysaccharides by consuming hydrogen and carbon dioxide to produce methane, thereby enhancing energy extraction from food. High concentrations have been associated with increased risk of obesity and constipation-predominant IBS, making it a potential therapeutic target for metabolic disorders.
02
Mechanism of action
Reduction of Methanobrevibacter smithii abundance via targeted antibiotics.
03
Biological functions
MethanogenesisHydrogen consumptionPolysaccharide digestion supportMicrobial interaction
04
Disease associations
ObesityConstipation-predominant IBSAltered glucose tolerance
05
Safety considerations
Potential disruption of gut microbiomeDevelopment of antibiotic resistance
06
Interacting drugs
Antibiotics targeting archaea
07
Biomarkers
M. smithii abundance in feces
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