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Target intelligence / Profile preview
Methicillin-resistant Staphylococcus aureus (MRSA)
- Target
- MRSA
- Molecular classification
- Bacteria, Pathogen
01
Overview
Methicillin-resistant Staphylococcus aureus (MRSA) is a group of Gram-positive bacteria notable for its resistance to beta-lactam antibiotics. It is a human pathogen responsible for a range of infections, from mild skin conditions to severe diseases. Resistance arises through the mecA gene encoding an altered penicillin-binding protein (PBP2a) with low affinity for beta-lactams. MRSA is globally prevalent and associated with significant morbidity/mortality.
- Other names
- Staphylococcus aureus (methicillin-resistant)MRSA
02
Mechanism of action
Resistance to beta-lactam antibiotics due to the presence of the mecA gene, which encodes an altered penicillin-binding protein (PBP2a) with low affinity for beta-lactams.
03
Biological functions
PathogenesisInfectionColonization
04
Disease associations
InfectionPneumoniaSepsisEndocarditisOsteomyelitisToxic Shock SyndromeSkin and Soft Tissue Infections
05
Safety considerations
Antibiotic resistanceTreatment failureSpread of infectionMorbidityMortalityEmerging resistance to alternative antibiotics
06
Interacting drugs
Methicillin
7 more in the full profile.
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