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Methionine--tRNA ligase (None)
- Target
- None
- Molecular classification
- Enzyme, Aminoacyl-tRNA synthetase
01
Overview
Methionine--tRNA ligase, also known as methionyl-tRNA synthetase (MetRS), is an essential enzyme that catalyzes the attachment of the amino acid L-methionine to its corresponding tRNA (tRNAMet). This process, called aminoacylation or "charging" of tRNA, is a critical step in protein biosynthesis. The enzyme ensures that methionine is correctly incorporated at the start and within polypeptide chains during translation. MetRS plays a dual role in translation: charging initiator tRNAs for initiation and elongator tRNAs for methionine incorporation during elongation. During cellular stress, post-translational modifications can alter substrate specificity, potentially serving protective roles.
- Other names
- Methionyl-tRNA synthetaseMethionyl-transfer RNA synthetaseMetRS
02
Mechanism of action
Inhibition of methionyl-tRNA synthetase, preventing tRNA charging with methionine.
03
Biological functions
Aminoacyl-tRNA biosynthesisProtein biosynthesisMethionine metabolismTranslation initiationTranslation elongation
04
Safety considerations
Off-target effects due to structural similarity with other aminoacyl-tRNA synthetases.Potential for mitochondrial toxicity if mitochondrial MetRS is affected.
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