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Methionine Aminopeptidase 1 (None)
- Target
- None
- Molecular classification
- Enzyme, Exopeptidase, Metalloproteinase
01
Overview
Methionine aminopeptidase 1 (MetAP1) is an enzyme responsible for the cotranslational removal of the N-terminal methionine from nascent proteins. This process is essential and highly conserved. MetAP1 regulates cell cycle progression, particularly at the G2/M phase transition. Inhibition of MetAP1 can induce apoptosis in cancer cells. It is a dinuclear metalloenzyme with a conserved "pita bread" fold. Selective inhibitors are being developed as anticancer drugs.
- Other names
- MAP1AMetAP1A
02
Mechanism of action
Inhibition of MetAP1 activity, leading to G2/M phase arrest and apoptosis
03
Biological functions
Protein maturationCell cycle regulationCell cycle progressionPeptide bond hydrolysis
04
Disease associations
Cancer
05
Safety considerations
Potential cross-reactivity with other metalloenzymesNeed for selective inhibitors to avoid off-target effects
06
Interacting drugs
Ovalicin
1 more in the full profile.
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