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Methionine Aminopeptidase 2
- Molecular classification
- Enzyme, Metallopeptidase, Aminopeptidase
01
Overview
Methionine aminopeptidase 2 (MetAP2) is a cytosolic metalloenzyme that catalyzes the hydrolytic removal of N-terminal methionine from newly synthesized proteins, a post-translational modification essential for proper protein maturation and function. It is a target for antiangiogenic drugs due to its role in endothelial cell proliferation and angiogenesis, particularly in cancer therapy. Overexpression is observed in some cancers and may play a role in fibrotic diseases. Natural products like fumagillin and ovalicin are potent inhibitors of MetAP2.
02
Mechanism of action
Inhibition of MetAP2 enzymatic activity, leading to suppression of angiogenesis and cell proliferation.
03
Biological functions
Protein maturationTranslation regulationProtein processingAngiogenesis regulationCell proliferation regulation
04
Disease associations
CancerFibrosis
05
Interacting drugs
Fumagillin
1 more in the full profile.
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