Target intelligence / Profile preview

Methionine Aminopeptidase II (MetAP2)

Target: MetAP2
Molecular classification: Enzyme, Metalloenzyme, Metalloprotease

Overview

Methionine aminopeptidase II (MetAP2) is a cytosolic metalloenzyme that catalyzes the hydrolytic removal of N-terminal methionine residues from nascent polypeptide chains during translation. It plays a crucial role in protein synthesis, angiogenesis, and lymphangiogenesis. MetAP2 is a therapeutic target for cancer due to its role in tumor vascularization.

Other names: METAP2

Mechanism of action

Irreversible binding to the active site of MetAP2, inhibiting its enzymatic activity.

Biological functions

Protein maturationCell proliferationAngiogenesisLymphangiogenesisRegulation of global protein synthesis

Disease associations

CancerFibrotic diseases

Interacting drugs

Fumagillin

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