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Target intelligence / Profile preview
Methionine aminopeptidase type 2 (MetAP2)
- Target
- MetAP2
- Molecular classification
- Enzyme, Exopeptidase, Dimetallohydrolase
01
Overview
MetAP2 is a cytosolic metalloenzyme that catalyzes the hydrolytic removal of N-terminal methionine residues from nascent proteins, a critical step in protein maturation and function. It plays an essential role in the regulation of protein synthesis by cotranslationally removing the initiator methionine. MetAP2 regulates angiogenesis, making it a target for anti-cancer therapies. Inhibitors targeting MetAP2 have shown efficacy in reducing hunger and inducing weight loss, leading to investigations into its potential use against metabolic diseases like type 2 diabetes.
- Other names
- METAP2
02
Mechanism of action
Irreversible inhibition of MetAP2's activity at its active site.
03
Biological functions
Protein maturationTranslation regulationAngiogenesis regulationProtein synthesis
04
Disease associations
CancerObesityMetabolic disorders
05
Interacting drugs
Fumagillin analogs (e.g., AGM1470/tNP470)
2 more in the full profile.
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