Target intelligence / Profile preview

Methionine gamma-lyase (MGL)

Target: MGL
Molecular classification: Enzyme, Pyridoxal 5'-phosphate (PLP)-dependent enzyme

Overview

Methionine gamma-lyase (MGL; EC 4.4.1.11) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catalyzes the degradation of sulfur-containing amino acids, primarily L-methionine, to produce methanethiol, ammonia, and 2-oxobutanoate. MGL is found in bacteria and plants but not in humans. It has therapeutic potential as an anticancer and antibacterial/antiparasitic agent.

Mechanism of action

Extracellular methionine depletion

Biological functions

Methionine catabolismDegradation of sulfur-containing amino acidsSeed development/germination under stress conditions (in plants)

Disease associations

CancerInfection

Safety considerations

ImmunogenicityBioavailabilityPotential effects on stress tolerance/germination rates in plants (when MGL is knocked out)

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