Methionine Synthase (MS)

Methionine synthase is an essential enzyme involved in one-carbon metabolism, specifically linking the folate cycle to the methionine cycle. It catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate (5-MeTHF) to homocysteine, resulting in the formation of methionine and tetrahydrofolate (THF). Methionine is an essential amino acid required for protein synthesis and as a precursor for S-adenosylmethionine, a universal methyl donor. Deficiency or dysfunction in methionine synthase leads to elevated levels of homocysteine—a risk factor for cardiovascular disease—and impaired DNA synthesis due to reduced THF availability.

Other names

MetHMeSe

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate (5-MeTHF) to homocysteine, resulting in the formation of methionine and tetrahydrofolate (THF).