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Target intelligence / Profile preview
Methionine Synthase Reductase (MTRR)
- Target
- MTRR
- Molecular classification
- Enzyme, Ferredoxin-NADP(+) reductase, Electron transferase
01
Overview
Methionine synthase reductase (MTRR) is an enzyme that maintains the active state of methionine synthase, which is essential for converting homocysteine to methionine. This reaction is crucial for amino acid metabolism, DNA methylation, and the synthesis of S-adenosylmethionine (SAM). Mutations in MTRR are associated with homocystinuria.
- Other names
- 5-methyltetrahydrofolate-homocysteine methyltransferase reductaseMSRcblEMTRR_HUMAN
02
Mechanism of action
N/A
03
Biological functions
Homocysteine remethylationMethionine biosynthesis/metabolic processFolate metabolic processDNA/cellular methylationS-Adenosylmethionine cycleMaintenance of methionine synthase activity
04
Disease associations
Homocystinuria
05
Safety considerations
Potential impact on DNA methylationDisrupted one-carbon metabolism
06
Biomarkers
Homocysteine levelsMethionine levels
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