Methionyl aminopeptidase type 1D, mitochondrial (METAP1D)

Methionyl aminopeptidase type 1D, mitochondrial (METAP1D) is a mitochondrial enzyme that catalyzes the removal of the initiator methionine from newly synthesized mitochondrial proteins. This N-terminal methionine excision is essential for protein maturation and subsequent modifications. METAP1D belongs to the peptidase M24A family and is localized to mitochondria, directed by an N-terminal leader peptide. Overexpression of METAP1D has been observed in colon cancer cell lines and colon tumors, suggesting a potential role in tumorigenesis. Mutations or altered function in METAP1D have also been associated with anemia of prematurity and optic atrophy 11. It is classified as an enzyme and considered a potential therapeutic target in oncology research, but there are no clinically approved drugs specifically targeting this protein to date[1][2][3][4][6].

Other names

Methionine aminopeptidase 1D, mitochondrialMAP1DMAP12_HUMANhMETAP1DQ6UB28

Drugs or inhibitors (where explored) would act by inhibiting the removal of N-terminal methionine from newly synthesized mitochondrial proteins, potentially impairing protein maturation