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Target intelligence / Profile preview
Methionyl-tRNA Synthetase (MetRS)
- Target
- MetRS
- Molecular classification
- Enzyme, Aminoacyl-tRNA Synthetase
01
Overview
Methionyl-tRNA synthetase (MetRS) is an essential enzyme that catalyzes the attachment of methionine to its cognate tRNA (tRNAMet). This process is critical for protein biosynthesis, ensuring that methionine is correctly incorporated during translation initiation. In mammals, MetRS interacts with AIMP3/p18, influencing DNA repair and tumor suppression. It is part of a larger multi-tRNA synthetase complex (MSC) involved in cell growth and stress responses. The enzyme's structure includes a catalytic Rossmann fold, KMSKS domain, and species-specific extensions that mediate interactions with other proteins or enhance activity.
02
Mechanism of action
Catalyzes the covalent linkage of methionine to tRNAMet using ATP
03
Biological functions
AminoacylationTranslation initiationMaintenance of translational fidelityCoordination between ribosome biogenesis and protein synthesis
04
Disease associations
CancerOther
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