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Methyl-coenzyme M reductase (MCR) is a key enzyme in methane metabolism, catalyzing the final step of methanogenesis and the initial step of anaerobic oxidation of methane (AOM) in archaea. It is essential for both the biological production and consumption of methane, making it central to global carbon cycling.
Catalyzes the reduction of methyl-coenzyme M (CH₃-S-CoM) with coenzyme B (HS-CoB), producing methane and a heterodisulfide product (CoM-S-S-CoB)
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