Methyl-CpG-binding domain protein 6 (MBD6)

Methyl-CpG-binding domain protein 6 (MBD6) is a member of the MBD protein family, capable of recognizing methyl-CpG sites on DNA through its conserved methyl-CpG-binding domain[1][2]. The protein has been structurally characterized in *Arabidopsis thaliana*, where it adopts the canonical fold associated with specific recognition of methylated cytosines (CpG dinucleotides) in DNA[1][2]. Its binding affinity to methylated DNA is significantly lower than mammalian MBD homologs due to absence of several key positively charged residues that typically enhance DNA interaction[1][2]. MBD6 exists as a monomer in solution and is implicated in repressing gene expression through binding to methylated DNA, contributing to epigenetic regulation and chromatin localization[1][2]. The functional relevance in human biology or disease is not established, with most available evidence from plant studies—though the domain and sequence conservation are notable.

Other names

MBD6KIAA1887Methyl-CpG-binding domain protein 6Methyl-CpG-binding protein MBD6