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Methylation Pathway Enzymes (N/A)
- Target
- N/A
- Molecular classification
- Enzyme, Transferase, Hydrolase, Methyltransferase
01
Overview
Methylation pathway enzymes are a group of enzymes responsible for catalyzing the transfer of methyl groups (–CH₃) to various substrates, including DNA, RNA, proteins, and small molecules. This process is fundamental in regulating gene expression, epigenetic modifications, protein function, and cellular metabolism. Key enzymes include DNA methyltransferases (DNMTs), histone methyltransferases, methionine adenosyltransferase (MAT), S-adenosylhomocysteine hydrolase (SAHH), and methionine synthase. Dysregulation is linked to cancer and developmental disorders.
- Other names
- DNA MethyltransferasesDNMTsHistone MethyltransferasesMethionine AdenosyltransferaseMATS-Adenosylhomocysteine HydrolaseSAHHMethionine Synthase
02
Mechanism of action
Inhibition or modulation of enzymatic activity related to methyl group transfer.
03
Biological functions
Gene expression regulationEpigenetic modificationDNA methylationHistone methylationProtein methylationCellular metabolismGenomic imprintingX-chromosome inactivationTransposable element suppressionOne-carbon metabolism
04
Disease associations
CancerDevelopmental disordersEpigenetic diseases
05
Safety considerations
Off-target effectsDisruption of normal methylation patternsPotential for developmental abnormalitiesDrug resistance
06
Biomarkers
DNA methylation patternsHistone methylation levelsSAM levelsSAH levelsHomocysteine levels
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