Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 pseudogene 1 (MTHFD1P1)

Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 pseudogene 1 (MTHFD1P1) is classified as a pseudogene, meaning it is a segment of DNA that shares sequence similarity with the protein-coding MTHFD1 gene but does not encode a functional protein. It retains homology with the functional gene involved in folate metabolism and one-carbon metabolism, but there is no evidence it acts as a drug target, encodes an active enzyme, or has a defined biological or therapeutic function in humans[5]. Notes: - MTHFD1P1 is a pseudogene and not a functional gene or protein; thus, it is not an enzyme, receptor, transporter, or therapeutic target[5]. - No evidence supports its use in disease, drug targeting, or biomarker development. - Many of the alternate names refer to the *functional* gene or its activities, not to the pseudogene itself. - This entry is considered "incorrect" as a drug target due to its pseudogene status and lack of functional or clinical relevance[5].

Other names

MTHFDL1MTHFDP15,10-Methylenetetrahydrofolate dehydrogenase, 5,10-Methylenetetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetaseMethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase pseudogeneMethylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase pseudogene 1