Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase pseudogene 7 (MTHFD2P7)

MTHFD2P7 is classified as a pseudogene and not as a protein-coding gene or bona fide molecular target. Pseudogenes are segments of DNA that resemble functional genes but generally lack the ability to encode proteins due to mutations, insertions, deletions, or premature stop codons. MTHFD2P7 is specifically annotated as a pseudogene of MTHFD2, an enzyme involved in mitochondrial folate metabolism, but there is no evidence to suggest MTHFD2P7 itself encodes an active protein or plays a role as a therapeutic target[6]. Clarification on correctness: - This entry is not considered a valid therapeutic target because it is a pseudogene, not an enzyme, receptor, transporter, or other molecular target classically recognized in biology or drug development[6]. - If the intent was to refer to the functionally active enzyme Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 (MTHFD2), that is a separate entity with important roles in one-carbon metabolism and cancer biology[2][4]. However, MTHFD2P7 is distinct and non-coding. Summary: MTHFD2P7 is a non-functional genomic sequence related to MTHFD2, annotated as a pseudogene, and as such, does not serve as a therapeutic target nor does it have recognized biological, pharmacological, or disease roles[6].

Other names

MTHFD2P7Methylenetetrahydrofolate dehydrogenase 2 pseudogene 7