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Methylenetetrahydrofolate dehydrogenase 2, methenyltetrahydrofolate cyclohydrolase pseudogene 5 (MTHFD2P5)
- Target
- MTHFD2P5
- Molecular classification
- Other (pseudogene)
01
Overview
MTHFD2P5 is a pseudogene that is related in sequence to the gene encoding methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), a mitochondrial enzyme involved in folate-mediated one-carbon metabolism in proliferating cells and cancer. Unlike its functional counterpart, MTHFD2P5 does not produce an active enzyme and is not implicated in any known biological pathway, disease mechanism, or as a drug target. Research and therapeutic interest focus on MTHFD2, not on its pseudogenes such as MTHFD2P5. Therefore, MTHFD2P5 is not considered a target for therapeutic intervention. If your query is about MTHFD2 (not its pseudogene), then that gene is a validated enzyme and emerging cancer drug target. If you intended to query the active enzyme MTHFD2, not the pseudogene, please clarify.
- Other names
- MTHFD2 pseudogene 5methylenetetrahydrofolate dehydrogenase 2 pseudogene 5MTHFD2P5
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