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Target intelligence / Profile preview
Methylenetetrahydrofolate dehydrogenase 2, methenyltetrahydrofolate cyclohydrolase pseudogene 6 (MTHFD2P6)
- Target
- MTHFD2P6
- Molecular classification
- Other (Pseudogene, not an enzyme, receptor, transporter, etc.), Related to the family of oxidoreductases and cyclohydrolases through homology to the functional gene MTHFD2
01
Overview
MTHFD2P6 is a pseudogene associated with the functional enzyme methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), an oxidoreductase in the mitochondrial folate-mediated one-carbon metabolism pathway[4][6]. Pseudogenes like MTHFD2P6 generally do not encode functional proteins and do not participate directly in biological processes or disease mechanisms. In contrast, the related enzyme MTHFD2 is a key metabolic regulator in proliferating cells and cancer, frequently upregulated in tumors and considered a promising therapeutic target in oncology. MTHFD2P6 itself is not a validated therapeutic target and there is no evidence for drugs, safety issues, or biomarker utility specific to this genetic element.
- Other names
- MTHFD2P6Methylenetetrahydrofolate dehydrogenase pseudogene 6
02
Mechanism of action
None (pseudogene).\nFor functional MTHFD2: Drugs inhibit folate metabolism, block nucleotide biosynthesis, disrupt cancer cell proliferation
03
Biological functions
None directly, as pseudogenes do not encode functional proteins.Functional relatives (MTHFD2) catalyze reactions in folate-mediated one-carbon metabolism linked to cell proliferation, DNA/RNA synthesis, and redox balance
04
Disease associations
Pseudogene itself: None established.Functional gene relatives: Cancer progression, poor prognosis, cell proliferation in malignanciesNo disease association directly documented for MTHFD2P6.
05
Safety considerations
None for the pseudogene.Functional MTHFD2 inhibition may affect normal proliferating cells
06
Interacting drugs
None (for the pseudogene).
1 more in the full profile.
07
Biomarkers
None for MTHFD2P6.Functional family members (esp. MTHFD2) used as prognostic markers in several cancers
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