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Methylmalonyl-coenzyme A (None)
- Target
- None
- Molecular classification
- Metabolite, Coenzyme A derivative
01
Overview
Methylmalonyl-coenzyme A (methylmalonyl-CoA) is a thioester compound formed by the linkage of coenzyme A to methylmalonic acid. It serves as a crucial metabolic intermediate, particularly in the conversion of certain amino acids and odd-chain fatty acids into succinyl-CoA, which then enters the tricarboxylic acid (TCA) cycle. It is also involved in polyketide biosynthesis in bacteria and plants.
- Other names
- methylmalonyl-CoAMethylmalonyl coenzyme A2-Methylmalonyl-CoA
02
Biological functions
Intermediate in amino acid catabolismIntermediate in fatty acid catabolismIntermediate in cholesterol catabolismPrecursor to succinyl-CoAPolyketide biosynthesis (in bacteria and plants)
03
Disease associations
Methylmalonic acidemia
04
Safety considerations
Accumulation can lead to metabolic disorders
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