Methylthioribose-1-phosphate isomerase 1 (MRI1)

Methylthioribose-1-phosphate isomerase 1 (MRI1) is a protein-coding enzyme involved in the methionine salvage pathway, mediating the reversible interconversion of methylthioribose-1-phosphate and methylthioribulose-1-phosphate[1][6]. Beyond its canonical metabolic role, MRI1 also promotes cell invasion, particularly in melanoma, through protein-protein interaction pathways that are independent of its isomerase activity[1]. Elevated expression is linked to metastatic melanoma, raising possible value in cancer biology, and genetic mutations have been associated with vanishing white matter disease and other neurological syndromes[1]. The enzyme shows identical protein binding activity and contributes to cytoskeletal changes in response to RhoA pathway activation, supporting a dual role in metabolism and cytoskeletal regulation[1].

Other names

Methylthioribose-1-phosphate isomeraseMRDIUNQ6390/PRO21135M1PiMTR-1-P isomeraseMGC3207Ypr118wmtnAS-methyl-5-thioribose-1-phosphate isomeraseTranslation initiation factor eIF-2B subunit alpha/beta/delta-like proteinmediator of RhoA-dependent invasionS-methyl-5-thioribose-1-phosphate isomerase 1MTNAmethylthioribose-1-phosphate isomerase homolog