Methyltransferase like 14 (METTL14)

Methyltransferase like 14 (METTL14) is a protein encoded by the human METTL14 gene. It functions primarily as a structural component within the N6-methyladenosine (m6A) methyltransferase complex, forming a heterodimer with METTL3. While METTL3 provides catalytic activity for transferring a methyl group from S‑adenosylmethionine to adenosine residues in RNA, METTL14 acts mainly as an RNA-binding scaffold that recognizes substrate RNAs rather than catalyzing reactions itself. The resulting m6A modification regulates various aspects of messenger RNA metabolism including splicing, stability, degradation, and translation efficiency. This process is essential for normal development—such as embryonic stem cell differentiation and neurogenesis—and has been implicated in diseases including several cancers. Aberrant function or expression can contribute to oncogenesis or other pathologies through dysregulation of gene expression at the post-transcriptional level[1][2][5].

Other names

METTL14methyltransferase like 14N6-adenosine-methyltransferase subunithmethyltransferase 14[3]

Drugs targeting this molecule would likely modulate mRNA methylation by affecting the activity or assembly of the METTL3-METTL14 complex; no approved drugs directly target METTL14 as of now.