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Target intelligence / Profile preview
Methyltransferase like 26 (METTL26)
- Target
- METTL26
- Molecular classification
- Predicted enzyme, Methyltransferase superfamily member, Protein of unknown molecular function
01
Overview
Methyltransferase like 26 (METTL26) is a protein-coding gene located on chromosome 16 in humans (previously designated C16orf13), encoding a putative methyltransferase. METTL26 is a member of the methyltransferase superfamily based on sequence similarity and phylogenetic analysis, but its precise molecular function, substrate specificity, and biological role have not been fully elucidated. It is expressed in several tissues and upregulated in various cancers, but no direct link to well-defined disease or drug response is established. METTL26 is part of a family of METTL proteins, some of which function in nucleic acid or protein methylation, though METTL26’s substrate and activity remain unknown[1][2][3][4].
- Other names
- METTL26C16orf13JFP2Chromosome 16 open reading frame 13methyltransferase-like 26UPF0585 protein C16orf13MGC13114
02
Mechanism of action
None reported
03
Biological functions
UnknownPossibly protein methylation or modification (inferred from phylogenetic clustering)
04
Disease associations
Cancer (high expression observed in several human cancer tissues)Other (underexpression also linked to disease consequences, but details currently sparse)
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