Methyltransferase-like protein 25 (METTL25)

Methyltransferase-like protein 25 (METTL25) is a predicted protein methyltransferase in humans, encoded by the METTL25 gene (HGNC:26228). It belongs to the methyltransferase-like gene family, which is structurally defined by the presence of an S-adenosylmethionine (SAM)-binding domain and a characteristic seven-beta-strand motif[1][3][5][6][9]. METTL25 is phylogenetically related to METTL25B, an RNA-modifying enzyme that methylates rRNA. However, the precise biochemical substrate, cellular localization, and physiological function of METTL25 remain uncharacterized. It is predicted to participate in methylation reactions and may play a role in epigenetic regulation analogous to other METTL family members[1][3][5][6][9]. Disease associations are limited, with current annotations referencing immunodeficiency-centromeric instability-facial anomalies syndrome[3]. No specific drugs, biomarkers, or safety issues are reported for METTL25. Additional experimental investigations are necessary to clarify its function and relevance as a therapeutic target.

Other names

C12orf26FLJ22789Probable methyltransferase-like protein 25Putative methyltransferase-like protein 25Methyltransferase-like 25

Null. No established drugs, therefore mechanism of action is not known or characterized