Target intelligence / Profile preview

Methyltransferase-like protein 25B (METTL25B)

Target
METTL25B
Molecular classification
Enzyme, RNA methyltransferase
01

Overview

Methyltransferase-like protein 25B (METTL25B) is a predicted RNA methyltransferase enzyme believed to catalyze rRNA (adenine-N6,N6-)-dimethyltransferase activity, indicating a probable role in the methylation of ribosomal RNA. While its precise biological functions are not well characterized, it is annotated to be involved in rRNA methylation, similar to other members of the METTL (Methyltransferase-like) protein family. There is no current experimental evidence strongly linking METTL25B to therapeutic targeting, drug interactions, or clinical safety concerns. Its disease association is limited to genetic syndromes identified in database annotations, with no clear mechanistic disease role described at this time[1][4][5][8][11].

Other names
Methyltransferase-like protein 25BMETTL25BC1orf66RRNAD1CGI-41ribosomal RNA adenine dimethylase domain-containing protein 1protein RRNAD1ribosomal RNA adenine dimethylase domain containing 1
02

Biological functions

rRNA methylationrRNA (adenine-N6,N6-)-dimethyltransferase activity
03

Disease associations

Other (reported associations with Palmoplantar Keratoderma, Nonepidermolytic, Focal Or Diffuse, and Dyschromatosis Symmetrica Hereditaria, but no direct evidence for major disease roles as a target)

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