Methyltransferase-like protein 27 (METTL27)

Methyltransferase-like protein 27 (METTL27, also known as WBSCR27) is a protein encoded by a gene frequently deleted in Williams-Beuren syndrome, a multisystem developmental disorder. Structurally, METTL27 is a Class I SAM-dependent methyltransferase with a canonical Rossmann fold, showing biochemical capacity to bind cofactors such as S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH)[1][2]. Despite extensive structural analyses, its substrate—whether nucleic acid, protein, or small molecule—remains unidentified, and no direct biological partners have been validated. The protein is hypothesized to function as a standalone methyltransferase. METTL27 is not implicated in rRNA methylation, histone modification, or protein methylation based on available experimental results[1]. Its role in disease, especially Williams-Beuren syndrome, is unexplored beyond genomic deletion association, and there is no evidence for its utility as a drug target, biomarker, or safety concern at this time[5].

Other names

METTL27WBSCR27Williams-Beuren syndrome chromosomal region 27 proteinWilliams Beuren syndrome chromosome region 27

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