Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Methyltransferase-like protein 3 (METTL3)
- Target
- METTL3
- Molecular classification
- Enzyme, Methyltransferase, RNA methyltransferase
01
Overview
METTL3 is the catalytically active subunit of the m^6A methyltransferase complex, which is responsible for installing N6-methyladenosine (m^6A) modifications on mRNA. This modification plays a crucial role in RNA stability, splicing, export, translation, and decay, and is implicated in various diseases including cancer and kidney disorders. METTL3 forms a heterodimer with METTL14 and interacts with other proteins like WTAP to regulate its function and localization. It is a target for small molecule inhibitors aimed at disrupting m^6A methylation in cancer therapy.
- Other names
- N6-adenosine-methyltransferase 70 kDa subunitMT-A70
02
Mechanism of action
Inhibition of m^6A methylation activity
03
Biological functions
Post-transcriptional gene regulationRNA methylation (m^6A)mRNA translation regulationDNA damage response
04
Disease associations
CancerTumorigenesisAcute kidney injuryRenal fibrosis
05
Safety considerations
Potential off-target effectsLong-term effects of m^6A dysregulation
06
Biomarkers
METTL3 expression levels in tumor tissue
Beyond the preview
Go deeper on Methyltransferase-like protein 3 (METTL3).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Methyltransferase-like protein 3 (METTL3).