METTL5 pseudogene 2 (METTL5P2)

METTL5 pseudogene 2 (METTL5P2) is a non-functional, likely non-coding pseudogene related to the METTL5 gene, which encodes an RNA methyltransferase that modifies 18S ribosomal RNA. Pseudogenes like METTL5P2 arise through gene duplication or retrotransposition events but typically lack the ability to produce an active protein product and are not considered therapeutic targets. In contrast, the active METTL5 enzyme has established roles in rRNA methylation and in the regulation of translational efficiency in cells, with emerging evidence of involvement in cancer cell biology and selenoprotein synthesis. Key clarification: - Any biological activity, disease association, or therapeutic targeting refers to the active METTL5 gene—not the METTL5P2 pseudogene. If your interest is in targeting methyltransferase activity for therapeutic reasons, the correct target would be the functional METTL5, not METTL5P2[1][2][3].

Other names

methyltransferase like 5 pseudogenemethyltransferase 5N6-adenosine pseudogene