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Mevalonate Pathway (MVA pathway)
- Target
- MVA pathway
- Molecular classification
- Biochemical Pathway, Metabolic Pathway
01
Overview
The mevalonate pathway is a crucial metabolic route that produces isoprenoids, including cholesterol, ubiquinone, and dolichol. It is targeted by statins to lower cholesterol and is implicated in various diseases.
- Other names
- Isoprenoid pathwayHMG-CoA reductase pathway
02
Mechanism of action
Statins inhibit HMG-CoA reductase
03
Biological functions
Sterol biosynthesisNon-sterol isoprenoid biosynthesisCholesterol synthesisUbiquinone synthesisDolichol synthesisHeme-A synthesisPrenylation of proteinsCell membrane integrityCell signaling
04
Disease associations
Cardiovascular diseaseAutoinflammatory diseasesCancerAutoimmune disordersNeurodegenerative disease
05
Safety considerations
Inhibition affects cholesterol and nonsterol branchesImplications in cancer therapy, autoimmune disorders, neurodegeneration
06
Interacting drugs
Statins
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