Target intelligence / Profile preview

mex-3 RNA binding family member B (MEX3B)

Target: MEX3B
Molecular classification: RNA-binding protein, Translational regulator

Overview

MEX3B is an RNA-binding protein involved in post-transcriptional regulation of gene expression. It binds to the 3' UTRs of target mRNAs to modulate their stability and translation. It plays a role in immune evasion in cancer by destabilizing HLA-A mRNA and also regulates developmental processes and Sertoli cell function.

Other names: MEX-3BRKHD3RNF195

Mechanism of action

Not applicable; MEX3B is a target, not a drug.

Biological functions

Post-transcriptional regulationmRNA destabilizationRegulation of translationImmune response regulationDevelopmental regulation

Disease associations

CancerMale infertilityImmune evasion

Safety considerations

Potential for off-target effects due to RNA-binding activity.

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