Target intelligence / Profile preview

MexY efflux pump (MexY)

Target: MexY
Molecular classification: Transporter, Resistance-Nodulation-Division (RND) efflux pump family

Overview

The MexY efflux pump is part of the MexXY-OprM tripartite efflux system in *Pseudomonas aeruginosa*, contributing significantly to antibiotic resistance by exporting a wide range of substrates, including aminoglycosides and other antibiotics, out of the bacterial cell.

Mechanism of action

Utilizes the proton motive force to export drugs from the cell

Biological functions

Export of antibioticsMultidrug resistanceContributing to cell physiologyExport of other harmful substances

Disease associations

InfectionAntimicrobial resistance

Safety considerations

Overexpression can lead to increased antibiotic resistance, complicating treatment

Interacting drugs

Aminoglycosides

2 more in the full profile.

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