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MG7 Antigen

Molecular classification: Tumor-associated antigen, Carbohydrate antigen, Protein antigen

Overview

The MG7 antigen is a tumor-associated antigen highly specific to gastric carcinoma, making it a valuable diagnostic marker. Recent research explores its potential as a therapeutic target for immunotherapies like CAR T-cell therapy and cancer vaccines. Expression levels correlate with disease progression and malignancy.

Mechanism of action

CAR T-cell therapy (MG7-targeted); Vaccine-induced T cell activation

Biological functions

Tumor cell recognitionImmune response elicitationMarker of malignant transformation

Disease associations

Gastric cancerCancer diagnosisCancer immunotherapy

Safety considerations

Potential for off-target effects in immunotherapyImmunogenicity of vaccine components

Biomarkers

Gastric cancer diagnosisGastric cancer prognosisTarget for CAR-T cell therapy selection

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